The present work focuses on the preparation of alginate -based aerogels in the form of \nparticles for their further study as potential drug delivery systems (solid dosage forms). The \ndripping method was used to prepare certain gel particles, and supercritical drying was used to \nobtain final alginate -based aerogel particles. Three model active substances (ketoprofen, \nnimesulide, loratadine) were impregnated into the obtained aerogels using the supercritical \nadsorption process. Using the method of X-ray analysis, it was shown that the in the obtained drug -\nloaded aerogels the corresponding active substances are in an amorphous state, and the stability of \nthis state after six months of storage is confirmed. In vitro dissolution tests for obtained drug -loaded \naerogels was performed. For each sample, an appropriate dissolution medium (with certain pH) \nwas determined. In vitro investigations showed the increasing of the release rate for all model active \nsubstances. Time was required to release and dissolve 50% of the active drug from drug -loaded \naerogels (T1/2), reduced in comparison with pure active drugs in crystalline form. Obtained results \nprovide insight into the application of alginate -based aerogel particles as a drug delivery system to \nimprove pharmacokinetic properties of certain active drugs.
Loading....